Many people take Tylenol and Benadryl together to alleviate their headaches. But is this a good idea? The answer depends on how you are taking the medication, and whether or not you have allergies to one of the ingredients. In some circumstances, taking both substances together can be dangerous.

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This is because they have similar effects on the central nervous system and may lead to a toxic reaction that causes sudden liver failure (hepatic necrosis). Tylenol blocks a substance called acetaminophen in your body from breaking down into ammonia and acid, which are necessary for protein metabolism. Benadryl inhibits an enzyme in your brain that breaks down histamine so you’ll produce less of it when you take prednisone or other anti-inflammatory drugs taken long term such as alendronate sodium (Fosamax), diclofenac potassium (Voltaren)or ibuprofen (Advil). That’s why taking Tylenol and Benadryl together doesn’t seem like a good idea. In other circumstances, taking the two medicines is not dangerous at all and can be quite effective in relieving your headache pain. This may be because they have different effects on the central nervous system-Tylenol blocks acetaminophen from breaking down into ammonia and acid while Benadryl only inhibits an enzyme that breaks down histamine so you’ll produce less of it when you take prednisone or other anti-inflammatory drugs taken long term such as alendronate sodium (Fosamax), diclofenac potassium (Voltaren)or ibuprofen (Advil). The bottom line: if

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