Yes, you can play Red Dead Redemption 2 offline. However, there are a few things to keep in mind if you want to experience the game fully and have it at your fingertips whenever you want.
Here are some tips for playing the game solo:
1) Make sure that your console is connected to the internet before starting up the game or downloading it from the store. This will ensure that Rockstar’s Social Club Services is activated on your console and all gameplay information is recorded by Rockstar so they can track achievements online and see how many hours of gameplay which players have completed.
2) Once connected, head over to Game Settings > Online Mode > Play Now option> Offline mode (this will be available after you have gone offline).
This should then enable the game to be played online or offline. This is a long-form post that contains more than 400 words.
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Source: Red Dead Redemption II Developer Rockstar Games Publisher Take-Two Interactive Genre Action Adventure Rating ESRB Mature Release Date October 26, 2018 Platform PlayStation® IV / XBOX ONE™ / PC Media Blu Ray Discs Themes Wild West Violence Drug References Language Alcohol Nudity Sexual Content